St. Paul's Senior Seminary, Kipalapala, was founded by the White Fathers in 1918 located at Ushirombo, in 1921 it was transferred to Utinta, on the shores of the Lake Tanganyika to serve four of their vicariates in sub - Sahara Africa, namely Bangwelo in Zambia, Nyassa in Malawi, Tanganyika and Unyanyembe. In 1922 it was decided by the Ordinaries of the four vicariates to move the Seminary from Utinta to a location more accessible and a central: Tabora was chosen a right place for the Seminary.
The location opted for was Kipalapala in Unyanyembe Vicariete. Construction works at Kipalapala started in 1924 and in February 1925 the building was solemnly blessed and the Seminary was named St. Paul's Senior Seminary. The goal of the Seminary was and still is, to form capable indigenous clergy and its motto is: Mihi Vivere Christus est "For me to live is Christ" ( Phil 1:21)
In 1988 the Seminary was affliated to the Urbaniana University Rome since 1988 and consequently it awards the B. A in Sacred Theology.